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Mickey S. Coffler, MD
HRC Fertility
San Diego (Oceanside)
Office:
3231 Waring Court
Suite M
Oceanside, CA 92056
Tel: (760) 758-2034
Fax: (760) 726-0122v
Newport Beach Office:
500 Superior Avenue
Suite 210
Newport Beach, CA 92663
Tel: (949) 287-5600
Fax: (949) 642-2750
Fullerton Office:
1950 Sunnycrest Dr.
Suite 2400
Fullerton, CA 92835
Tel: (714) 738-4200
Fax: (714) 738-4496
Laguna Hills Office:
23961 Calle De La
Magdalena
Suite 503
Laguna Hills, CA 92653
Tel: (949) 472-9446
Fax: (949) 472-9023
SPOKEN LANGUAGES
English, Hebrew, Romanian
EDUCATION
Undergraduate
B.Sc. - Summa Cum Laude, Technion - Israel Institute of Technology, The
Ruth and Bruce Rappaport Faculty of Medicine, Haifa, Israel. (9/84-7/88)
Graduate
M.D. - Cum Laude, Technion - Israel Institute of Technology, The Ruth
and Bruce Rappaport Faculty of Medicine, Haifa, Israel. (9/88-1/91)
Internship
Beilinson Medical Center, Petach-Tikva, Israel. (3/91-2/92)
Obstetrics and Gynecology Residency
Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa,
Israel. (3/92-12/98)
Department of Obstetrics and Gynecology, Case Western Reserve
University (MetroHealth)/Cleveland Clinic Foundation, Cleveland, Ohio.
(1/02-12/05)
Reproductive Endocrinology and Infertility Fellowship
Department of Reproductive Medicine, University of California (San
Diego), La Jolla, California. (1/99-12/01, 1/05-12/07)
SPECIALTY BOARDS
ABOG, OB/GYN: Certified, Exp. 12/31/2013
ABOG, REI: Written exam – passed, 6/2009
ACADEMIC APPOINTMENTS AND TEACHING
1/2005 – Present Clinical Instructor, University of California (San Diego),
La Jolla, California.
1/2002 – 12/2004 Teaching medical students, OB/GYN Clerkship,
MetroHealth M.C., Cleveland, OH.
1/1999 – 12/2001 Assistant Clinical Professor, University of California
(San Diego), La Jolla, California.
3/1993 – 12/1998 Teaching medical students, OB/GYN Clerkship,
Rambam Medical Center, Haifa, Israel.
3/1993 – 12/1998 Lecturer, Midwives Course, Rambam Medical Center
Nursing School, Haifa, Israel.
1/1994 – 12/1998 Chief Instructor - Ob/Gyn course for nurses, Rambam
Medical Center Nursing School, Haifa, Israel.
AWARDS
1985 President’s Award for Excellence in Medical Studies, Technion -
Israel Institute of Technology, Haifa, Israel.
1986 President’s Award for Excellence in Medical Studies, Technion -
Israel Institute of Technology, Haifa, Israel.
1987 President’s Award for Excellence in Medical Studies, Technion -
Israel Institute of Technology, Haifa, Israel.
1988 President’s Award for Excellence in Medical Studies, Technion -
Israel Institute of Technology, Haifa, Israel.
2002 Department of OB/GYN Award for Excellence in Academics,
Metrohealth Medical Center, Cleveland OH.
2003 Department of OB/GYN Award for Excellence in Academics,
Metrohealth Medical Center, Cleveland OH.
2003 Mortimer Rosen Award for highest CREOG scores, Cleveland
OB/GYN Society, Cleveland, OH.
2004 Department of OB/GYN Award for Excellence in Academics,
Metrohealth Medical Center, Cleveland OH.
2004 Mortimer Rosen Award for highest CREOG scores, Cleveland
OB/GYN Society, Cleveland, OH.
ACADEMIC SERVICE
2007 - 2008 Research Protocol Reviewer, General Clinical Research
Center, University of California (San Diego), La Jolla,
California.
MEMBER OF SOCIETIES
American College of Obstetricians and Gynecologists
American Society for Reproductive Medicine
Society for Reproductive Endocrinology and Infertility
Society of Reproductive Surgeons
HOSPITAL AFFILIATIONS
St Jude Medical Center, Fullerton (5/08 – current)
Saddleback Medical Center, Laguna Hills (7/08 – current)
Tri City Medical Center, Oceanside (10/08 – current)
UCSD Medical Center, La Jolla (1/04 – current)
PUBLICATIONS
1. Coffler MS, Kol S, Drugan A, Itskovitz-Eldor J. Early transvaginal
embryo aspiration: a safer method for selective reduction in high
order multiple gestations. Human Reproduction 1999; July
14(7):1875-8
2. Coffler MS, Patel K, Dahan MH, Malcom PJ, Kawashima T, Deutsch
R, Chang RJ. Evidence for abnormal granulosa cell responsiveness
to follicle-stimulating hormone in women with polycystic ovary
syndrome. J Clin Endocrinol Metab. 2003 Apr 88(4):1742-7.
3. Nevo O, Avisar E, Tamir A, Coffler MS, Sujov P, Makhoul IR.
Neonatal course and outcome of twins from reduced multifetal
pregnancy versus non-reduced twins. Isr Med Assoc J. 2003 Apr
5(4):245-8.
4. Patel K, Coffler MS, Dahan MH, Yoo RY, Lawson MA, Malcom PJ,
Chang RJ. Increased luteinizing hormone secretion in women with
polycystic ovary syndrome is unaltered by prolonged insulin
infusion. J Clin Endocrinol Metab. 2003 Nov 88(11):5456-61.
5. Coffler MS, Patel K, Dahan MH, Yoo RY, Malcom PJ, Chang RJ.
Enhanced granulosa cell responsiveness to follicle-stimulating
hormone during insulin infusion in women with polycystic ovary
syndrome treated with pioglitazone. J Clin Endocrinol Metab. 2003
Dec 88(12):5624-31.
6. Patel K, Coffler MS, Dahan MH, Malcom PJ, Deutsch R, Chang RJ.
Relationship of GnRH-stimulated LH release to episodic LH secretion
and baseline endocrine-metabolic measures in women with
polycystic ovary syndrome. Clin Endocrinol (Oxf). 2004 Jan
60(1):67-74.
7. Mehta RV, Patel KS, Coffler MS, Dahan MH, Yoo RY, Archer JS,
Malcom PJ, Chang RJ. Luteinizing hormone secretion is not
influenced by insulin infusion in women with polycystic ovary
syndrome despite improved insulin sensitivity during pioglitazone
treatment. J Clin Endocrinol Metab. 2005 Apr;90(4):2136-41.
8. Dahan MH, Coffler MS, Patel KS. Oral contraceptives for inducing
ovulation delay in orthodox Jewish women. A report of 2 cases. J
Reprod Med. 2005 Mar;50(4):284-6.
9. Wachs DS, Coffler MS, Malcom PJ, Chang RJ. Comparison of
follicle-stimulating-hormone-stimulated dimeric inhibin and estradiol
responses as indicators of granulosa cell function in polycystic ovary
syndrome and normal women.
J Clin Endocrinol Metab. 2006 Aug;91(8):2920-5.
10. Wachs DS, Coffler MS, Malcom PJ, Chang RJ. Serum Anti-Mullerian
Hormone Concentrations Are Not Altered by Acute Administration of
Follicle Stimulating Hormone in Polycystic Ovary Syndrome and
Normal Women. J Clin Endocrinol Metab. 2007 May;92(5):1871-4.
11. Wachs DS, Coffler MS, Malcom PJ, Shimasaki S, Chang RJ.
Increased androgen response to follicle-stimulating hormone
administration in women with polycystic ovary syndrome. J Clin
Endocrinol Metab. 2008 May;93(5):1827-33.
12. Rosencrantz MA, Wachs DS, Coffler MS, Malcom PJ, Donohue M,
Chang RJ. Comparison of inhibin B and estradiol responses to
intravenous FSH in women with polycystic ovary syndrome and
normal women. Hum Reprod. 2010 Jan;25(1):198-203
13. Rosencrantz MA, Coffler MS, Haggan A, Duke KB, Donohue MC,
Shayya RF, Su HI, Chang RJ. Clinical evidence for predominance of
delta-5 steroid production in women with polycystic ovary
syndrome. J Clin Endocrinol Metab. 2011 Apr;96(4):1106-13
REVIEW ARTICLES
14. Pretorius DH, Borok NN, Coffler MS, Nelson TR. Three-Dimensional
Ultrasound in Obstetrics and Gynecology. Radiol Clin North Am 2001
May;39(3):499-521
15. Chang RJ, Coffler MS. Polycystic ovary syndrome: early detection
in the adolescent. Clin Obstet Gynecol 2007 Mar;50(1):178-87
BOOK CHAPTERS
1. M Bronshtein, MS Coffler, EZ Zimmer. The cardiovascular system.
In M Bronshtein, EZ Zimmer (Ed.), Transvaginal sonography of the
normal and abnormal fetus. The Parthenon Publishing Group, 2001.
2. EZ Zimmer, MS Coffler, M Bronshtein. The abdomen and
abdominal wall. In M Bronshtein, EZ Zimmer (Ed.), Transvaginal
sonography of the normal and abnormal fetus. The Parthenon
Publishing Group, 2001.
ABSTRACTS
1998 Kol S, Coffler M, Drugan A, Itskovitz-Eldor J. Early transvaginal
embryo aspiration: a safer method for selective reduction in high
order multiple gestations. The Annual Meeting of the American
Society for Reproductive Medicine, San Francisco, CA.
1999 Itskovitz-Eldor J, Thaler I, Kol S, Coffler M, Drugan A. The
outcome of selective transvaginal embryo reduction in high order
multiple pregnancies. 19th Annual Meeting of the Society For
Maternal-Fetal Medicine, San Francisco, CA.
1999 Blumenfeld Z, Ritter M, Coffler M, Goldman S, Gonen Y, Stoler J,
Kerner H, Linn R. The combination of ART & pulsatile GnRH or
HMG/hCG: the role of inhibin-B levels in hypogonadotropic
azoospermia treatment. The Annual Meeting of the Society of
Gynecologic Investigation, Atlanta, GA.
1999 Blumenfeld Z, Ritter M, Coffler M, Goldman S, Gonen Y, Linn R.
The combination of ART & pulsatile GnRH or HMG/hCG: the role of
inhibin-B levels in hypogonadotropic azoospermia treatment. First
world conference of A PART, Venice, Italy.
2000 Coffler MS, Teixeira Filho FL, Malcom PJ, Chang RJ. Ovarian
responsiveness to recombinant human FSH in normal women and
women with PCOS. The Annual Meeting of the Society of
Gynecologic Investigation, Chicago, IL.
2000 Amato P, Bromberg D, Coffler M, Chang RJ. Serum homocysteine
levels are not elevated in PCOS. The Annual Meeting of the Society
of Gynecologic Investigation, Chicago, IL.
2000 Coffler MS, Patel KS, Chang RJ. Hyperinsulinemia and Ovarian
Response to FSH Stimulation in PCOS. The international congress
on Reproductive Medicine, Obstetrics & Gynecology: Challenges in
the 3rd Millenium, Tel-Aviv, Israel.
2000 Pretorius DH, Hull AD, Nelson TR, Coffler M, Daneshmand S.
Patients undergoing 3-dimensional ultrasound: review of referrals
for 111 patients. 10th World Congress on Ultrasound in Obstetrics
and Gynecology, Zagreb, Croatia.
2001 Coffler MS, Patel KS, Dahan MH, Chang RJ. Hyperinsulinemia and
Ovarian Response to FSH Stimulation in PCOS. The Annual Meeting
of the Society of Gynecologic Investigation, Toronto, Canada.
2001 Ciaraldi TP, Coffler MS, Erickson GF, Soules MR, Henry RR, Chang
RJ. Intracellular Insulin and IGF-1 Signaling in the Polycystic Ovary.
83rd Annual Meeting of the Endocrine Society, Denver, CO.
2001 Pretorius DH, Hull AD, Nelson TR, James GM, Coffler MS.
Distribution and Potential Impact of Three-Dimensional Ultrasound
on Clinical Service Referral Patterns. American Institute of
Ultrasound in Medicine 45th Annual Convention, Orlando, FL.
2001 Coffler MS, Patel KS, Dahan MH, Malcom PJ, Chang RJ. Ovarian
response to FSH stimulation in PCOS following pioglitazone
administration. The 57th Annual Meeting of the American Society
for Reproductive Medicine, Orlando, FL.
2002 Dahan MH, Yoo RY, Patel KS, Stratford RR, Coffler MS, Malcom PJ,
Chang RJ Comparison of 17-Hydroxyprogesterone Responses to
GnRH Agonist in PCOS Treated with Metformin. 84th Annual Meeting
of the Endocrine Society, San Francisco, CA.
2002 Ciaraldi TP, Chu NV, Aroda V, Bandukwala R, Chandran M, Coffler
MS, Chang RJ, Mudaliar SR, Henry RR. Insulin resistance in the
polycystic ovary syndrome involves intrinsic defects in skeletal
muscle glucose uptake and insulin action. The annual meeting of
the American Diabetes Association.
2002 Plodkowski R, Aroda V, Chu N, Sathyaprakash R, Coffler MS,
Chang RJ, Mudaliar SR, Henry RR, Ciaraldi TP. In vivo insulin
resistance in the polycystic ovary syndrome involves tissue specific
alterations in insulin signaling. The annual meeting of the American
Diabetes Association.
2002 Patel KS, Coffler MS, Dahan MH, Malcom PJ, Chang RJ. Pituitary
Sensitivity to GnRH in Polycystic Ovary Syndrome (PCOS): Dose-
Response Comparison in PCOS and Normal Women. The Annual
Meeting of the Society of Gynecologic Investigation, Los Angeles,
CA.
2002 Dahan H, Abu II, Patel KS, Coffler MS, Yoo RY, Nguyen SL,
Krikorian R, Chang RJ. An Assessment of Polycystic Ovary
Syndrome (PCOS) Patients’ Perceptions of Medical Experiences. The
Annual Meeting of the Society of Gynecologic Investigation, Los
Angeles, CA.
2002 Dahan MH, Abu II, Patel KS, Coffler MS, Yoo RY, Nguyen SL,
Krikorian R, Chang RJ. Perceptions of Obesity Related Medical
Experiences Among Polycystic Ovary Syndrome (PCOS) Patients.
The Annual Meeting of the Society of Gynecologic Investigation, Los
Angeles, CA.
2002 Coffler MS, Patel KS, Dahan MH, Yoo RY, Kawashima-Slosson T,
Deutsch R, Chang RJ. Progesterone Responsiveness to FSH
Stimulation in Normal Women and Women with PCOS. The Annual
Meeting of the Society of Gynecologic Investigation, Los Angeles,
CA.
2003 Dahan MH, Yoo R, Patel K, Stratford R, Coffler M, Malcom P, Chang
RJ. Endocrine Responses to Increasing Metformin Dose in
Unresponsive Polycystic Ovary Syndrome Patients. The Annual
Meeting of the Society of Gynecologic Investigation, Washington,
DC.
2003 Dahan MH, Yoo R, Coffler M, Patel K, Malcom P, Chang RJ. A
Comparison of Endocrine Responses to Metformin in Polycystic
Ovary Syndrome. The Annual Meeting of the Society of Gynecologic
Investigation, Washington, DC.
2003 Patel KS, Coffler MS, Dahan MH, Yoo RY, Chang RJ, Malcom PJ,
Deutsch R. Suppression of Increased Pituitary LH Secretion in
Polycystic Ovary Syndrome by Hyperinsulinemia. The Annual
Meeting of the Society of Gynecologic Investigation, Washington,
DC.
2003 Dahan MH, Coffler MS, Patel KS, Yoo RY, Malcom PJ, Chang RJ.
Increased 17-hydroxyprogesterone responsiveness to gonadotropin
stimulation in hyperthecosis compared to polycystic ovary syndrome
(PCOS). The 59th Annual Meeting of the American Society for
Reproductive Medicine.
2005 Archer JS, Coffler M, Yu J, Wachs D, Yoo R, Chang R. Effect of
Estrogen and Progesterone on Free Fatty Acid-Induced Insulin
Resistance in Postmenopausal Women. The 61st Annual Meeting of
the American Society for Reproductive Medicine.
2007 Coffler MS, Wachs DS, Park AS, Patel KS, Dahan MH, Yoo RY,
Malcom PJ, Chang RJ. Serum Anti-Mullerian Hormone (AMH) Levels
Are Not Influenced by Insulin Infusion in Women with PCOS. The
Annual Meeting of the Society of Gynecologic Investigation, Reno,
NV.
2007 Wachs DS, Coffler MS, Malcom PJ, Chang RJ. Serum Anti-Mullerian
Hormone Concentrations Are Not Altered by Acute Administration of
Follicle Stimulating Hormone in Polycystic Ovary Syndrome and
Normal Women. The Annual Meeting of the Society of Gynecologic
Investigation, Reno, NV.
2007 Wachs DS, Coffler MS, Rey R, Malcom PJ, Chang RJ. Enhanced
Androgen Responses to Follicle Stimulating Hormone Stimulation in
Women with Polycystic Ovary Syndrome Compared to Normal
Women. The Annual Meeting of the Society of Gynecologic
Investigation, Reno, NV.
2007 Park AS, Wachs DS, Coffler MS, Yoo RY, Malcom PJ, Chang RJ.
Serum Anti-Mullerian Hormone (AMH) Concentrations in
Oligomenorrheic Adolescents without Evidence of
Hyperandrogenism and Girls with Polycystic Ovary Syndrome. The
Annual Meeting of the Society of Gynecologic Investigation, Reno,
NV.
2007 Coffler MS, Wachs DS, Park AS, Yoo RY, Dahan MH, Patel KS,
Malcom PJ, Chang RJ. Similar 17-Hydroxyprogesterone Responses
to Gonadotropin Stimulation in Adult Women and Adolescent Girls
with PCOS. 89th Annual Meeting of the Endocrine Society, Toronto,
Canada.
2008 Coffler MS, Rosencrantz MA, Park AS, Wachs DS, Malcom PJ, Rey
R, Chang RJ. Ovarian Dose-Responsiveness to Recombinant hCG in
Normal Women and Women with PCOS. 90th Annual Meeting of the
Endocrine Society, San Francisco, CA.
2008 Park AS, Coffler MS, Wachs DS, Yoo RY, Klein K, Oberfield SE,
Chang RJ. Serum Anti-mullerian Hormone Concentrations are
Elevated in Oligomenorrheic Girls without Evidence of
Hyperandrogenism. 90th Annual Meeting of the Endocrine Society,
San Francisco, CA.
2008 Rosencrantz MA, Coffler MS, Wachs DS, Haggan A, Chang RJ.
Inhibin B as a surrogate for granulosa cell responsiveness to
intravenous FSH administration in women with polycystic ovary
syndrome and normal women. The 64th Annual Meeting of the
American Society for Reproductive Medicine, San Francisco, CA.
2009 Rosencrantz MA, Coffler MS, Park AS, Shayya R, Ramos-Haggan A,
Chang RJ. Comparison of hCG-stimulated androgen production in
women with polycystic ovary syndrome and normal women. The
65th Annual Meeting of the American Society for Reproductive
Medicine, Atlanta, GA.
2010 Rosencrantz MA, Coffler MS, Shayya R, Haggan A, Chang RJ. Role
of Endogenous LH Secretion on Theca Cell Responsiveness to
Provocative Gonadotropin Stimulation in Women with Polycystic
Ovary Syndrome. 92nd Annual Meeting of the Endocrine Society,
San Diego, CA.
2010 Khoury CD, Frederick J, Coffler M, Johnson D, Karabinus D, Potter
DA. Pre-implantation genetic screening using micro-array based 24
chromosome aneuploidy screening: aneuploidy incidence with and
without Microsort. sperm separation. The 66th Annual Meeting of
the American Society for Reproductive Medicine, Denver, CO.
2011 Khoury CD, Coffler M, Frederick J, Potter D. Preimplantation
Genetic Screning (PGS) with Trophectoderm Biopsy (TB) Following
Embryo Cleavage Biopsy. A Case Series. The 59th Annual Meeting
of The Pacific Coast Reproductive Society, Rancho Las Palmas, CA.
2012 Khoury CD, Coffler M, Frederick J, Potter D. Improved blastocyst
development using a single step medium versus a sequential
medium. The 60th Annual Meeting of The Pacific Coast Reproductive
Society, Rancho Las Palmas, CA.
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